When you hear Vitamin B-12, what comes to mind? Anemia? Irreversible nerve damage? Vitamin B-12 may not be on your radar but that’s about to change particularly with Boomers. With age, a low B-12 status is associated with more rapid cognitive impairment and dementia including Alzheimer’s disease. Neuro-inflammation and oxidative stress are associated with these conditions and may compromise B12 metabolism.
Data from the International Journal of Geriatric Psychiatry, the Journal of Alzheimer’s Disease, and Proceedings of the National Academy of Sciences indicate that elevated homocysteine is a risk factor for Alzheimer’s. Homocysteine-lowering, long-term treatment with B vitamins appears to slow decline in memory, to slow the rate of brain atrophy in mild cognitive impairment and reduces amount of shrinkage in regions of the brain commonly affected by Alzheimer’s disease.
Listen now to find out the recommended amounts of Vitamin B-12 and the blood levels now considered potentially symptomatic.
Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial. International Journal of Geriatric Psychiatry
Preventing Alzheimer’s disease-related gray matter atrophy by B-vitamin treatment. Proceedings of the National Acadmeny of Sciences of the USA
Brain atrophy in cognitively impaired elderly: the importance of long-chain ω-3 fatty acids and B vitamin status in a randomized controlled trial. The American Journal of Clinical Nutrition
Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms—the Beyond Ageing Project: a randomized controlled trial. The American Journal of Clinical Nutrition
Nutrition for a Changing World. Pope, Nizielski and McCook. 2016 W.H. Freeman and Company